ACKR1 (Atypical Chemokine Receptor 1): ACKR1, formerly known as DARC (Duffy Antigen Receptor for Chemokines), acts as a decoy receptor for chemokines, modulating the immune response and inflammatory pathways. Unlike typical chemokine receptors, ACKR1 does not signal intracellularly but serves to sequester chemokines, reducing their availability to signal through conventional chemokine receptors. This unique mechanism plays a role in the regulation of inflammation and in protecting tissues from excessive damage during immune responses. Variations in ACKR1 are associated with susceptibility to infection and the severity of inflammatory diseases....